产品介绍
Product Description
Biochem/physiol Actions
Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
Dorzolamide is a potent carbonic anhydrase II inhibitor.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D -25 to -35°, c = 1 in methanol |
| color | white to beige |
| solubility | DMSO: 5 mg/mL (clear solution, warmed) |
| storage temp. | room temp |
| SMILES string | CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |
| InChI | 1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 |
| InChI key | IAVUPMFITXYVAF-XPUUQOCRSA-N |
| Gene Information | human ... CA2(760) |
