产品介绍
Product Description
Biochem/physiol Actions
Cell penetrant and potent a chemical chaperone-like modulator of endoplasmic reticulum proteostasis that alleviates ER stress.
KM04794 is a cell penetrant and potent a chemical chaperone-like modulator of endoplasmic reticulum proteostasis that alleviates ER stress. It prevents protein aggregation and cell death caused by ER stressors (such as thapsigargin and dithiothreitol) and a mutant insulin. KM04794 enhances insulin production in pancreatic β cells. Apparently it binds directly to ER molecular chaperone BiP (binding immunoglobulin protein).
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(NNC(C1=CC=CC(C(F)(F)F)=C1)=O)COC2=CC=CC=C2SCC3=CC=C(Cl)C=C3 |
| InChI | 1S/C23H18ClF3N2O3S/c24-18-10-8-15(9-11-18)14-33-20-7-2-1-6-19(20)32-13-21(30)28-29-22(31)16-4-3-5-17(12-16)23(25,26)27/h1-12H,13-14H2,(H,28,30)(H,29,31) |
| InChI key | CTHFEQURMFRYPT-UHFFFAOYSA-N |
