General description
The human immune system has six FcγRs-FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA and FcγRIIIB. FcγRIIIB/CD32 (Fc fragment of IgG receptor IIb) is an inhibitory receptor that is located on human chromosome 1q23.
Anti-CD32 Antibody detects endogenous levels of total CD32 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human CD32.
Immunogen Range: 277-326
Biochem/physiol Actions
FcγRIIIB/CD32 (Fc fragment of IgG receptor IIb) controls the generation of autoantibodies and their effector roles. During a viral memory response, FcγRIIB blocks the generation of inflammatory type I IFN from plasmacytoid dendritic cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 34 kDa |
| species reactivity | human, rat, mouse |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:1000,western blot: 1:500-1:1000 |
| NCBI accession no. | P31994 |
| UniProt accession no. | P31994 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... FCGR2B(2213) |
