产品介绍
Product Description
Application
Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR.
Biochem/physiol Actions
5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp. However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.
技术参数
Specifications
| Quality Segment | 200 |
| assay | ≥98.0% (HPLC) |
| form | powder |
| optical purity | enantiomeric ratio: ≥99.5:0.5 (HPLC) |
| mp | 270-280 °C |
| storage temp. | 2-8°C |
| SMILES string | N[C@@H](Cc1c[nH]c2ccc(F)cc12)C(O)=O |
| InChI | 1S/C11H11FN2O2/c12-7-1-2-10-8(4-7)6(5-14-10)3-9(13)11(15)16/h1-2,4-5,9,14H,3,13H2,(H,15,16)/t9-/m0/s1 |
| InChI key | INPQIVHQSQUEAJ-VIFPVBQESA-N |
