General description
Th (tyrosine hydroxylase) is a homotetramer that has regulatory, catalytic and tetramerization domains. The gene is located on human chromosome llpl5.
Immunogen
The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser19.
Immunogen Range: 10-59
Biochem/physiol Actions
Th (tyrosine hydroxylase) plays an important role in catecholamine synthesis as it helps in the hydroxylation of L-tyrosine to l-DOPA (l-3,4-dihydroxyphenylalanine). Th gene mutation results in tyrosine hydroxylase deficiency.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 58 kDa |
| species reactivity | mouse, rat, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:5000,immunofluorescence: 1:100-1:500,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000 |
| NCBI accession no. | P07101 |
| UniProt accession no. | P07101 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer19) |
| Gene Information | human ... TH(7054) |
