General description
This gene encodes a protein which is a member of thecysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phaseof cell apoptosis. Caspases exist as inactive proenzymes whichundergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form theactive enzyme. This protein cleaves and activates caspases 6, 7 and9, and the protein itself is processed by caspases 8, 9 and 10. Itis the predominant caspase involved in the cleavage of amyloid-beta4A precursor protein, which is associated with neuronal death inAlzheimer′s disease. Alternative splicing of this gene results intwo transcript variants that encode the same protein. [provided byRefSeq].
Biochem/physiol Actions
This mouse CASP3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S26 of mouse CASP3.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| biological source | (Mouse) |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| mol wt | 109343Da |
| species reactivity | mouse |
| technique(s) | dot blot: 1:500 |
| isotype | IgG |
| NCBI accession no. | NP_033940.1 |
| storage temp. | -10 to -25°C |
| target post-translational modification | phosphorylation (pSer26) |
| Gene Information | mouse ... Casp3(12367) |
