Biochem/physiol Actions
Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, whereas the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
| biological source | human |
| recombinant | expressed in insect cells |
| assay | ≥80% (SDS-PAGE) |
| form | frozen liquid |
| mol wt | ~41.8 kDa |
| packaging | pkg of 5 μg |
| concentration | 850 μg/mL |
| color | clear colorless |
| NCBI accession no. | NM_000546 |
| UniProt accession no. | P04637 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... TP53(7157) |
