General description
Z 200775 is a competetive AMPA/kainate receptor antagonist.
ZK 200775 is a selective AMPA/kainite receptor antagonist with very low affinity for NMDA associated binding sites (Ki for CNQX binding site = 32 nM vs. 2.8 uM for DCKA binding site.) ZK 200775 displays superior PK and safety profiles in in vivo studies compared to quinoxalinedione antagonists such as NBQX, showing no effects on motor behavior or cardiac events at efficacious doses in rat. Additionally, unlike other quinoxalinediones, ZK 200775 is water soluble, making this a desirable tool compound for in vivo studies.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | off-white to light brown |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | O.OP(O)(=O)CN1C(=O)C(=O)Nc2cc(c(cc12)N3CCOCC3)C(F)(F)F |
| InChI | 1S/C14H15F3N3O6P.H2O/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9;/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25);1H2 |
| InChI key | RYQLMFHPDNKPKY-UHFFFAOYSA-N |
