产品介绍
Product Description
Application
Naltrexone hydrochloride has been used:
- as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
- to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
- in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
技术参数
Specifications
| form | powder |
| Quality Segment | 100 |
| originator | Novartis |
| storage temp. | 2-8°C |
| SMILES string | Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6 |
| InChI | 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1 |
| InChI key | RHBRMCOKKKZVRY-ITLPAZOVSA-N |
| Gene Information | human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280) |
