产品介绍
Product Description
Biochem/physiol Actions
LW-3-254, a derivative of MM0299, is an orally bioavailable and blood-brain barrier penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity. LW-3-254 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumors, which induces toxicity in glioma stem-like cells. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol.
Orally bioavailable and blood-brain barrier penetrant, selective and potent inhibitor of lanosterol synthase (LSS)
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
