Anti-LNPK antibody produced in rabbit，100UL，HPA014205-100UL，Sigma

General description

The gene KIAA1715 is also referred to as LNP1 (Lunapark1) and encodes a member of the conserved lunapark protein family. The protein is characterized by two transmembrane domains and a zinc finger motif. It is found to localize to ER (endoplasmic reticulum) tubule junctions in both yeast and mammalian cells. The gene is mapped to human chromosome 2q31.

Immunogen

lunapark, ER junction formation factor recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Mammalian Lnp1 (Lunapark1) encoded by the gene KIAA1715 functions in stabilizing nascent three-way ER (endoplasmic reticulum) junctions. Newly formed three-way junctions remain within the ER network if they succeed to acquire Lnp1. If these junctions do not acquire Lnp1, they undergo rapid ring closure. In yeast cells, if Lnp1 function is disrupted, the cortical ER network collapses and large sectors of the cortex that lack ER are formed.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Other Notes

Corresponding Antigen APREST72900

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.