General description
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Immunogen
Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V), according to the protein PAK1/PAK2/PAK3.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 61-67 kDa, 68-74 kDa |
| species reactivity | mouse, human, rat |
| concentration | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100,indirect immunofluorescence: 1:100-1:200 |
| isotype | IgG |
| immunogen sequence | (R-S-TP-M-V) |
| NCBI accession no. | NP_001121638.1,NP_001122092.1,NP_002568.2 |
| UniProt accession no. | Q13177 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr423/pThr402/pThr421) |
| Gene Information | human ... PAK1(5058), PAK2(5062), PAK3(5063) |
