产品介绍
Product Description
Biochem/physiol Actions
Endogenous agonist of neuromedin-U receptor 1 (NMUR1) and neuromedin-U receptor 2 (NMUR2)
Neuromedin U-23 (Neuromedin U), a neuropeptide, is endogenous agonist of neuromedin-U receptor 1 (EC50 = 0.17 nM) and neuromedin-U receptor 2 (EC50 = 1.4 nM) that regulates blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function. Neuromedin U-23 decreases body weight and food intake and increases core body temperature in mice when administered at a dose of 36 µg/animal. It appears that neuromedin U regulates epithelial cell differentiation and barrier immunity through interaction with neuromedin-U receptor 1 present at small intestine eosinophils.
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Hygroscopic
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | (Powder or Lyophilized powder or film) |
| storage condition | desiccated |
| color | white to off-white |
| storage temp. | -10 to -25°C |
| SMILES string | O=C([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC(CNC(CNC([C@H](CO)NC([C@H]2CCCN2C([C@@H](NC([C@H](C(C)C)NC(C3N(CCC3)C(CNC([C@@H](NC([C@H](CC4=CC=C(C=C4)O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H](N)CC5=CC=C(C=C5)O)=O)=O)C(C)C)=O) |
