General description
The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a metalloreductase that belongs to the STEAP family. It is localized in secretory and endocytic pathway organelles. The STEAP2 gene is mapped to human chromosome 7q21.13.
Immunogen
a 16 amino acid peptide from near the carboxy-terminus of human STEAP2.
Biochem/physiol Actions
The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) being localized in Golgi membrane and cytoplasmic vesicles, may have a critical role in the endocytic pathway. It is highly expressed in prostate carcinomas (PCa) and promotes tumor invasion and migration. Along with STEAP3 and 4, STEAP2 levels are implicated in favoring copper and iron uptake. Studies on targeted STEAP2 knockdown have reported a reduction in PCa progression.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP4307.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 54 kDa |
| species reactivity | mouse, human |
| technique(s) | immunofluorescence: suitable,immunohistochemistry: suitable,indirect ELISA: suitable,western blot: suitable |
| UniProt accession no. | Q8NFT2 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... STEAP2(261729) |
