General description
GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is part of the GATA transcription factor family and the gene encoding it is localized on human chromosome Xp11.23.
Immunogen
Peptide with sequence C-DAEAYRHSPVFQ from the internal region of the protein sequence according to NP_002040.1.
Biochem/physiol Actions
GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
| biological source | goat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | human, canine, mouse, rat |
| technique(s) | indirect ELISA: suitable,western blot: suitable |
| UniProt accession no. | P15976 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... GATA1(2623) |
