General description
Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Immunogen
Peptide sequence around phosphorylation site of Serine 149 (F-R-S(p)-L-P).according to the protein Cdc25b.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~62 kDa |
| species reactivity | mouse |
| concentration | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype | IgG |
| immunogen sequence | (F-R-SP-L-P) |
| NCBI accession no. | NP_001104545.1 |
| UniProt accession no. | P30306 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer149) |
| Gene Information | mouse ... Cdc25b(12531) |
