General description
NOS1 (nitric oxide synthase 1) is one of the NOS (nitric oxide synthase) isoforms found in the heart. It is located on human chromosome 12q24.2-31. It is mainly localized in the sarcoplasmic reticulum (SR).
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.
Immunogen
Peptide sequence around aa. 850-854 (F-N-S-V-S), according to the protein NOS1.
Application
Anti-NOS1 (Ab-852) antibody has been used in immunocytochemistry .
Biochem/physiol Actions
NOS (nitric oxide synthase) produce nitric oxide in the heart.It regulates myocardial function and plays an important role in the remodeling of human (ICM) ischemic cardiomyopathy.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~160 kDa |
| species reactivity | mouse, rat, human |
| concentration | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200 |
| isotype | IgG |
| immunogen sequence | (F-N-S-V-S) |
| NCBI accession no. | NP_000611.1 |
| UniProt accession no. | P29475 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... NOS1(4842) |
