General description
Unconventional prefoldin RPB5 interactor (URI) is an oncogene required for the survival of some human carcinomas and is often amplified and over-expressed in subsets of carcinomas from ovary, breast, stomach, and lung. Activation of URI contributes an important mechanism for activating mitochondrial S6K1-BAD signaling and promoting cell survival through disabling PP1γ-dependent negative feedback inhibition. URI can negatively modulate RNA polymerase II subunit 5 (RPB5) and mediates resistance of cells to cisplatin.
Immunogen
Synthetic peptide derived from the C-terminus of the human URI protein.
Features and Benefits
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Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| recombinant | expressed in proprietary host |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | SP215, monoclonal |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | bovine, mouse |
| technique(s) | flow cytometry: 1:100,immunohistochemistry: 1:100 |
| isotype | IgG |
| UniProt accession no. | O94763 |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... URI1(8725) |
