产品介绍
Product Description
General description
Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.
Application
γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.
技术参数
Specifications
| assay | ≥95% (HPLC) |
| form | lyophilized |
| composition | Peptide Content, ≥85% |
| storage condition | protect from light |
| storage temp. | −20°C |
