General description
The gene encoding arginase 1 (ARG1), spanning 10-15kb on genomic DNA, is localized on human chromosome 6q23.2. It consists of eight exons. The protein consists of 322 amino acids and is expressed in the liver, red blood cells, lactating mammalian glands and the kidney.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Arginase 1 (ARG1) is a liver enzyme involved in the hydrolysis of arginine to form ornithine and urea. In addition to urea cycle, ARG1 is also implicated in various cellular processes, such as macrophage-mediated cytotoxicity and regulation of immune response. The encoded protein is also involved in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury. Deficiency or mutations in the gene leads to a rare urea cycle disorder, argininemia.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
| species reactivity | human |
| packaging | kit of 96 wells (12 strips x 8 wells) |
| technique(s) | ELISA: suitable |
| input | sample type plasma sample type serum sample type cell culture supernatant(s) |
| assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 2.05 ng/mL standard curve range: 2.048-500 ng/mL |
| detection method | colorimetric |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... ARG1(383) |
