产品介绍
Product Description
General description
N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.
Application
N-Butyldeoxynojirimycin has been used:
- in the inhibition of glycolipid synthesis in neuroblastoma cells
- in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
- in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.
Biochem/physiol Actions
N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.
α-glucosidase Inhibitor
技术参数
Specifications
| assay | ≥98% (TLC) |
| Quality Level | 200 |
| form | film (dried in situ) |
| solubility | water: 9.80-10.20 mg/mL, clear, colorless |
| storage temp. | 2-8°C |
| SMILES string | CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
| InChI | 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 |
| InChI key | UQRORFVVSGFNRO-UTINFBMNSA-N |
| Gene Information | human ... UGCG(7357) |
