产品介绍
Product Description
General description
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
Biochem/physiol Actions
This mouse TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S387 of mouse TSC1.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
技术参数
Specifications
| biological source | (Mouse) |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| mol wt | 128746Da |
| species reactivity | mouse |
| technique(s) | dot blot: 1:500 |
| isotype | IgG |
| NCBI accession no. | NP_075025.2,Q9Z136 |
| storage temp. | -10 to -25°C |
| target post-translational modification | phosphorylation (pSer387), phosphorylation (Ser387) |
| Gene Information | mouse ... Tsc1(64930) |
