General description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
Immunogen
A phospho specific peptide corresponding to residues surrounding Y693 of human STAT4
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
| biological source | rabbit |
| Quality Level | 100 |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| species reactivity | human, rat, mouse |
| concentration | 0.976 mg/mL |
| technique(s) | immunohistochemistry: 1:50-1:200,western blot: 1:500-1:2000 |
| UniProt accession no. | Q14765 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr693) |
| Gene Information | human ... STAT4(6775) |
