General description
SRY-box (SOX) transcription factors bind the minor groove of DNA to modulate gene expression. SRY-box 17 (SOX17) regulates a variety of developmental processes such as endoderm formation. SOX17 is an antagonist to Wnt/β-catenin pathway cell signaling. SOX17 is a potential biomarker for breast cancer carcinogenesis and progression.
Immunogen
Synthetic peptide directed towards the C terminal region of human SOX17
Biochem/physiol Actions
Rabbit polyclonal anti-SOX17 antibody reacts with canine, human, and pig SRY (sex determining region Y)-box 17 transcription factors.
The SOX17 gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: GTDPSQPAELLGEVDRTEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSHGA
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 44 kDa |
| species reactivity | human, pig, dog |
| concentration | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| web metadata keyword.default | SOX17 antibody peptide sequence GTDPSQPAELLGEVDR,SOX17 rabbit polyclonal antibody,anti-SOX17 antibody Sigma-Aldrich,anti-SOX17 antibody endoderm formation,anti-SOX17 antibody for breast cancer research,anti-SOX17 antibody for developmental biology,anti-SOX17 antibody rabbit,anti-SOX17 antibody signaling antagonist,anti-SOX17 antibody with sodium azide,anti-SOX17 antibody,anti-SRY-box 17 antibody for research,lab-grade anti-SOX17 antibody,purified anti-SOX17 antibody 1x PBS,western blot anti-SOX17 antibody |
| NCBI accession no. | NP_071899 |
| UniProt accession no. | Q9H6I2 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... SOX17(64321) |
