产品介绍
Product Description
Application
Chidamide may be used as an enhancer of zeste homolog 2 (EZH2) inhibitor and study the antileukemia effects in vivo in leukemia-bearing nude mouse models
Biochem/physiol Actions
Chidamide (CS055, HBI-8000, Tucidinostat) is an orally available benzamide that inhibits against class I histone deaceylases HDAC1/2/3/8 (IC50 of 95/160/67/733 nM), class II2b HDAC10 (IC50 = 78 nM), and class IV HDAC11 (IC50 = 432 nM), but not class IIa HDAC4/5/7/9 or IIb HDAC10 (IC50 >30 μM). Chidamide effectively upregulates cellular acetylation levels of histone H3 and H4 (3 μM for 24 h in SKM-1 and HEL cultures) and exhibits anti-cancer efficacy both in cultures and in vivo.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
