产品介绍
Product Description
Biochem/physiol Actions
Potent and selective FK506-binding protein 51 (FKBP51) inhibitor that stimulates neurite growth in cultures and exhibits antidepressant-like effects in vivo.
SAFit2 is a brain-penetrant, potent and selective FK506-binding protein 51 inhibitor (Ki = 6 nM/FKBP51 vs. >50 μM/FKBP52) that enhances neurite growth in murine Neuro 2A (N2a) cultures (1-10 nM) and improves neuroendocrine feedback and stress-coping behavior in mice in vivo (20 mg/kg i.p.).
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C([C@@H](C1CCCCC1)C2=CC(OC)=C(C(OC)=C2)OC)N3CCCC[C@H]3C(O[C@@H](C4=CC(OCCN5CCOCC5)=CC=C4)CCC(C=C6)=CC(OC)=C6OC)=O |
| InChI | 1S/C46H62N2O10/c1-51-39-20-18-32(28-40(39)52-2)17-19-38(34-14-11-15-36(29-34)57-27-24-47-22-25-56-26-23-47)58-46(50)37-16-9-10-21-48(37)45(49)43(33-12-7-6-8-13-33)35-30-41(53-3)44(55-5)42(31-35)54-4/h11,14-15,18,20,28-31,33,37-38,43H,6-10,12-13,16-17,19,2 |
| InChI key | ZDBWLRLGUBSLPG-FDHYQTMZSA-N |
