产品介绍
Product Description
Application
Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:
- to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
- to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
- to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
- to study its stand-alone effect on cytarabine-sensitive and resistant cells.
Biochem/physiol Actions
Histone deacetylase inhibitor; anti-cancer agent.
Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: soluble 13 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1 |
| InChI | 1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+ |
| InChI key | QRPSQQUYPMFERG-LFYBBSHMSA-N |
