General description
Anti-Progesterone receptor antibody detects endogenous levels of total progesterone receptor protein.
The progesterone receptor (PR) gene is mapped to human chromosome 11q22–23. The gene encodes for two isoforms, namely PR-A and PR-B, each of which is transcribed from a specific promoter region. The encoded receptor belongs to the family of steroid hormone receptors.
Immunogen
The antiserum was produced against synthesized peptide derived from human Progesterone Receptor.
Immunogen Range: 261-310
Application
Anti-Progesterone receptor antibody produced in rabbit has been used in western blotting and immunohistochemistry.
Biochem/physiol Actions
Progesterone receptor (PR) mediates the actions of progesterone which is essential to maintain pregnancy. PR is known to regulate the genes involved in the process of cell cycle, cell adhesion, invasion, differentiation, proliferation, inflammation, and apoptosis. PR expression might serve as a biomarker in axillary lymph node (ALN) metastasis. Abnormal expression of PR is observed in breast cancer.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 98 kDa |
| species reactivity | rat, mouse, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:5000,immunofluorescence: 1:100-1:500,immunohistochemistry: 1:50-1:100 |
| NCBI accession no. | P06401 |
| UniProt accession no. | P06401 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... PGR(5241) |
