General description
ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) possesses a Sec7 domain which is crucial for its activity. This protein is expressed in the brain and the gene encoding it is localized on human chromosome 20.
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Biochem/physiol Actions
ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) activates ADP-ribosylation factors (ARFs) by exchanging guanosine diphosphate (GDP) with guanosine triphosphate (GTP). It aids in the release of type I tumor necrosis factor receptor (TNFR1) from human umbilical vein endothelial cells. Mutation in the ARFGEF2 gene has been linked to microcephaly and periventricular heterotopia.
The antibody detects endogenous levels of total ARFGEF2 protein.
Features and Benefits
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Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 202 kDa |
| species reactivity | mouse, human |
| concentration | 3.4 mg/mL |
| technique(s) | immunohistochemistry: 1:50- 1:200,western blot: 1:200-1:1000 (Cell Lysate) |
| isotype | IgG |
| accession no. | NP_006411.2 |
| UniProt accession no. | Q9Y6D5 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... ARFGEF2(10564) |
