L6H21，25MG，SML3498-25MG，Sigma

Biochem/physiol Actions

L6H21 is an orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist and shows a great inhibitory effect on pro-inflammatory cytokines expression levels. L6H21 binds to the hydrophobic pocket of MD2 in a dose-dependent manner with a high affinity (Kd = 33.3 µM) and inhibits the ability of LPS to recognize TLR4/MD2 complex. Suppresses NLRP3 inflammasome activation and may serve as a potential candidate for the treatment of allograft rejection.
Orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist