General description
PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) is also known as polycystin-L/ transient receptor potential polycystin-3 (TRPP3). It is expressed in brain, kidney, heart, skeletal muscle, spleen, testis, retina and in the bipolar neurons in the tongue taste buds. TRPP3 is present on the surface membrane and/or endoplasmic reticulum membrane of cells. It belongs to the PKD2 gene family. PKD2L1 is mapped to human chromosome 10q25.
Immunogen
Synthetic peptide of human PKD2L1
Biochem/physiol Actions
PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) participates in hedgehog signaling, intestinal development and sour tasting. It controls ciliary Ca2+ concentration. Mutations in PKD2 results in autosomal dominant kidney disease (ADPKD).
Features and Benefits
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Physical form
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous glycerol solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:20-1:100 |
| accession no. | NP_057196 |
| UniProt accession no. | Q9P0L9 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... PKD2L1(9033) |
