General description
Swine H1N1 Hemagglutinin Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States. The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic. Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin. The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups.
Immunogen
Hemagglutinin antibody was raised against a synthetic peptide from the novel swine influenza Hemagglutinin protein. The peptide sequence is unique from the peptide sequence for product SAB3501247 and SAB3501245. This antibody is a cognate pair with product number SAB3501248. The immunogen is located within amino acids 150 - 200 of Swine H1N1 Hemagglutinin.
Application
Hemagglutinin antibody can be used for the detection of the Hemagglutinin protein from the H1N1 strain of swine influenza A in ELISA. It will detect 2 ng of free peptide at 1 μg/mL.
Physical form
Supplied in PBS containing 0.02% sodium azide.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| species reactivity | Influenza A virus subtype H1N1 (swine) |
| concentration | 1 mg/mL |
| technique(s) | ELISA: suitable |
| isotype | IgG |
| UniProt accession no. | C4AL34 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
