Biochem/physiol Actions
Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene.
Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. It is a prodrug of tazarotenic acid, which specifically activates RARb and RARg, only weakly activates RARa, and is inactive at retinoid X receptors (RXRs). In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.
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| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to very faintly yellow |
| solubility | DMSO: >15 mg/mL |
| originator | Allergan |
| storage temp. | 2-8°C |
| SMILES string | S1CCC(c2c1ccc(c2)C#Cc3ncc(cc3)C(=O)OCC)(C)C |
| InChI | 1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3 |
| InChI key | OGQICQVSFDPSEI-UHFFFAOYSA-N |
