产品介绍
Product Description
General description
Ester precursor of the STING(A230/I230)-selective agonist BDW568-OH with no activity toward STING(G230).
BDW568 is an ester precursor of the STING(A230/I230)-selective agonist BDW568-OH with no activity toward STING(G230). Upon entering cells, BDW568 is hydrolyzed by carboxylesterase 1 (CES1) to the active metabolite BDW568-OH, which in turn induces cellular type-I interferon (IFN-I) signaling (EC50 = 7.6 μM by ISRE reporter assay using THP-1 cells, 4.1 μM using STING-/- THP-1 expressing STING with H71, A230, Q293).
Disclaimer
Hygroscopic Store with dessicant
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated,protect from light |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
