General description
Vacuolar protein sorting 4 homolog B (Vps4B) is a member of the AAA protein family (ATPases associated with diverse cellular activities) and is a homolog of yeast Vps4 protein. In humans, two of yeast protein paralogs have been identified as Vps4A and Vps4B. Both share high degree of amino acid sequence. The gene for Vps4B resides on human chromosome 18.
Application
Anti-VPS4B antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Vacuolar protein sorting 4 (Vps4) mediates endosomal membrane protein sorting, retroviral budding, and cytokinesis by recognizing membrane-associated endosomal sorting complexes required for transport (ESCRT-III) assemblies and catalysing their disassembly.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~50 kDa |
| species reactivity | human, mouse |
| concentration | ~1.0 mg/mL |
| technique(s) | immunoprecipitation (IP): 10-20 μg using lysate of mouse 3T3 cells,western blot: 2-4 μg/mL using whole extracts of G361 cells |
| UniProt accession no. | O75351 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... VPS4B(9525) |
